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Identification of BRAF 3'UTR Isoforms in Melanoma

Here, we show that BRAF mRNAs exist in at least two isoforms, which differ in the length and sequence of their 3′UTRs, and we discuss the implications that this discovery may have in terms of BRAF biology.


Journal of Investigative Dermatology, 2015

Autori esterni: Andrea Marranci (Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy and Department of Biology, University of Pisa, Pisa, Italy), Andrea Tuccoli (Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy), Marianna Vitiello (Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy and University of Siena, Siena, Italy), Elisa Mercoledi (Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy), Samanta Sarti (Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy and University of Siena, Siena, Italy), Simone Lubrano (Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy and University of Siena, Siena, Italy), Monica Evangelista (IFC-CNR, Pisa), Antonella Fogli (Sezione di Genetica Oncologica, Dipartimento di Medicina di Laboratorio e Diagnostica Molecolare, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy), Camilo Valdes (Center for Computational Science, University of Miami, Miami, Florida, USA), Massimo Dal Monte (Department of Biology, University of Pisa, Pisa, Italy), Maria A Caligo (Sezione di Genetica Oncologica, Dipartimento di Medicina di Laboratorio e Diagnostica Molecolare, Università di Pisa, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy), Enrico Capobianco (Center for Computational Science, University of Miami, Miami, Florida, USA and Laboratory of Integrative Systems Medicine (LISM), CNR, Pisa, Italy), Nicholas Tsinoremas (Center for Computational Science, University of Miami, Miami, Florida, USA), Laura Poliseno (Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy and Institute of Clinical Physiology (IFC), CNR, Pisa, Italy)
Autori IIT:

Francesco Russo

Foto di Francesco Russo

Tipo: Articoli su riviste ISI
Area di disciplina: Computer Science & Engineering

Attività: Biologia computazionale