IIT Home Page CNR Home Page

Early Detection of Central Visual Function Decline in Cone-RodDystrophy by the use of Macular Focal Cone Electroretinogram

PURPOSE:
To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD).
RESULTS:
Macular focal cone ERG follow-up allowed a clear-cut identification of CRD patients as stationary or progressive, in agreement with visual acuity follow-up. In all progressive patients, fERG declined whenever visual acuity declined, and--in 50% of the cases--fERG loss anticipated acuity loss of several years.
CONCLUSIONS:
Macular focal cone ERG represents a sensitive assay to detect, categorize, and follow the progression of central retinal dysfunction in CRD. Its use as a diagnostic tool in CRD may help anticipate, for an individual patient, the likelihood and rate of further disease progression before visual acuity loss has occurred.


Invest Ophthalmol Vis Sci, 2013

Autori esterni: Lucia Galli-Resta (Istituto Neurofisiologia CNR), Marco Piccardi (Institute of Ophthalmology, Policlinico Gemelli, Roma), Lucia Ziccardi (Bietti Foundation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)), Antonello Fadda (Tecnologie e Salute, Istituto Superiore di Sanità, Roma), Angelo Minnella (Institute of Ophthalmology, Policlinico Gemelli, Roma), Dario Marangoni (Institute of Ophthalmology, Policlinico Gemelli, Roma), Giorgio Placidi (Institute of Ophthalmology, Policlinico Gemelli, Roma), Benedetto Falsini (Istituto di Oftalmologia, Università Cattolica del S. Cuore)
Autori IIT:

Tipo: Articoli su riviste ISI
Area di disciplina: Mathematics
Da pagina 6560 a pagina 6590

Attività: Algoritmica per reti wireless