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Circulating Non-Coding RNAs as Clinical Biomarkers

Non-coding RNAs (ncRNAs) are frequently dysregulated in cancer and other diseases and have shown great potential as tissue-based markers for cancer classification and prognostication. ncRNAs are present in membrane-bound vesicles, such as exosomes, in extracellular human body fluids. Since miRNAs and the other ncRNAs circulate in the bloodstream in highly stable, extracellular forms, they may be used as blood-based biomarkers. The identification and use of non-invasive biomarkers is a fundamental tool for biomedical research but optimal and standardized conditions for processing blood samples for RNA measurement remain to be established. In this chapter we discuss recent discoveries, controversial topics on circulating ncRNAs and present several public resources recently developed.


2015

External authors: Flavia Scoyni (Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy), Alessandro Fatica (Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy), Alfredo Ferro (Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy), Alfredo Pulvirenti (Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy), Rosalba Giugno (Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy)
IIT authors:

Francesco Russo

Foto di Francesco Russo

Type: Bookchapter in book with an international publisher
Field of reference: Computer Science & Engineering

Activity: Biologia computazionale