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OCDB: the first overall database collecting genes, miRNAs and drugs for Obsessive-Compulsive Disorder

Motivation: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive  and  unwilling  thoughts  (obsessions)  which  give  rise  to  anxiety. The  patients  feel forced to perform a behavior (compulsions) related to the obsession. They suffer very much since they struggle to resist to their compulsions while feel to be required to perform them. The  World  Health  Organization  ranks  OCD  as  1  of  10  most  disabling  medical  conditions worldwide(1).  The  OCD  is  a  pathology, among  all  anxiety  disorders,  for which  hereditary component  has  been  demonstrated.  Consequently  online  resources  collecting  and integrating scientific discoveries and genetic evidences about OCD would be very helpful. Methods:  Several  studies  supporting  the  existence  of  genetic  susceptibility  factors  have been  reported  (2). The  most  studied  genes  are  SLC1A1,  SLC6A4,  SLC6A2,  HTR2A,  HTR2C and,more recently, NTRK3 and SLITRK1. Very few studies reported the role of miRNAs downregulating disease  candidate  genes  and  drug  targets  in  anxiety  disorders  and  OCD(3)(4)  . Here we propose a manually curated database, OCDB, which will be soon available on line showing  relationship  between  OCD–associated  genes,  OCD–miRNAs  and  OCD–drugs  with particular  emphasis  on  drug  targets  and  their polymorphisms.  We maintain  the therapeutical and side effects of the drugs, miRNA and drug targets polymorphisms, miRNA binding  and  information  about  the candidate disease  genes  (location,  alias,  their  use  as putative  biomarkers,  and  so  on).  Relevant  pathologies  (OCD  or  associated  disease  such  as social phobia and schizophrenia) and experimental conditions (i.e., number of samples, used softwares, and  so  on) will  be also  reported. The  database  has  been  created  using MySQL, Apache and PHP. It contains relations among 45 genes, 24 miRNAs and 7 drugs. Several tools for  advanced  search  and  browsing  have  been  integrated.  An export  function  to  download search results in various formats (CSV, XLS, TXT) will be available.  Results: Our database is an essential resource to improve knowledge on this pathology and to support genome-wide analysis studies. For instance using our database  the gene HTR2C results  to  be  simultaneously  a  target  of  the Clomipramina drug  and  of  miR-22(4),  and contain polymorphisms. Such information was separately reported in 5 publications. Finally, genetic  scientific  results  concerning OCD related to  autism  and  other  anxiety  disorder  are also reported. For all these reasons OCDB may represent an important knowledge base for researchers working on anxiety disorders.


Bioinformatics Italian Society (BITS) Annual Meeting 2014, Roma, 2014

Autori esterni: Anna Privitera (Department of Clinical and Molecular Biomedicine, University of Catania, Italy), Rosario Distefano (Department of Computer Science, University of Verona, Verona, Italy), Alfredo Ferro (Department of Clinical and Molecular Biomedicine, University of Catania, Italy), Alfredo Pulvirenti (Department of Clinical and Molecular Biomedicine, University of Catania, Italy), Rosalba Giugno (Department of Clinical and Molecular Biomedicine, University of Catania, Italy)
Autori IIT:

Francesco Russo

Foto di Francesco Russo

Tipo: Abstract/poster in Atti di convegno nazionale
Area di disciplina: Computer Science & Engineering

Attività: Biologia computazionale